Dublin Core
Title
Effect of metals on antibiotic sensitivity, growth, and biofilm-forming capacity of B. subtilis subsp. spizizenii
Abstract
B. subtilis is normally considered a soil organism, it can be also found in the animal and
human gastrointestinal tract. Bacillus subtilis subsp. spizizenii is a type of Bacillus subtilis complex.
It shares up to 99% of homology with B. subtilis CU1, which can be represented as a probiotic
strain. Metal compounds found in soil or used in agriculture can easily enter the food chain and end
up in our gut. Gram-positive bacteria (e.g. Bacillus spp.) have good adsorptive capacity for metals
due to high peptidoglycan and teichoic acid content in cell walls. There is some evidence that
certain metals inside the intestine play an important role in influencing growth and functionality of
specific probiotic strains. Some of them have inhibitory, while others have an activating effect on
bacteria. This study revealed that metal compounds increased antibiotic susceptibility of B. subtilis
subsp. spizizenii. Higher concentrations of metal solutions inhibited growth of tested bacteria.
Culture did not show affinity to form biofilms before or after addition of metal solutions
human gastrointestinal tract. Bacillus subtilis subsp. spizizenii is a type of Bacillus subtilis complex.
It shares up to 99% of homology with B. subtilis CU1, which can be represented as a probiotic
strain. Metal compounds found in soil or used in agriculture can easily enter the food chain and end
up in our gut. Gram-positive bacteria (e.g. Bacillus spp.) have good adsorptive capacity for metals
due to high peptidoglycan and teichoic acid content in cell walls. There is some evidence that
certain metals inside the intestine play an important role in influencing growth and functionality of
specific probiotic strains. Some of them have inhibitory, while others have an activating effect on
bacteria. This study revealed that metal compounds increased antibiotic susceptibility of B. subtilis
subsp. spizizenii. Higher concentrations of metal solutions inhibited growth of tested bacteria.
Culture did not show affinity to form biofilms before or after addition of metal solutions
Keywords
antibiotic susceptibility, biofilms, MIC, metals
Identifier
2637-2835
DOI
10.14706/JONSAE2021323